Necrolisis tóxica epidérmica: caso clínico / Toxic epidermal necrolysis: clinical case
Rev. chil. reumatol
; 21(2): 72-76, 2005. ilus
Article
en Es
| LILACS
| ID: lil-432950
Biblioteca responsable:
CL1.1
ABSTRACT
Toxic epidermal necrolysis is a potentially fatal disease due to allergic reactions to drugs. We report on a 58 years old female, that presented Raynaud sphenomenon during 20 years. During the last year, she developed polyarthritis of hands, shoulders, knees and ankles. Rheumatoid factor (RF), antinuclear antibodies (ANA) and U_ ribonucleoprotein (U1 RNP) were present, and Mixed connective tissue disease was suspected. Because of a poor response to methotrexate the patient received leflunomide. Two weeks later, she began with fever, pruritus and generalized edema. Within days this affected her neck, thorax, eyes and oral mucous. She had bullaes and areas of epidermic detachment. A toxic epidermal necrolysis was diagnosed and treated with IV immunoglobulins. The lesions disappeared successfully. In addition to the dermatological problem, the patient later presented ocular complications that required the transplant of both corneal, with the sub-sequent loss of one of her eyes.
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Síndrome de Stevens-Johnson
/
Isoxazoles
Límite:
Female
/
Humans
Idioma:
Es
Revista:
Rev. chil. reumatol
Asunto de la revista:
REUMATOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Portugal