Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
Mem. Inst. Oswaldo Cruz
; 103(8): 773-777, Dec. 2008. ilus, tab
Article
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| LILACS
| ID: lil-502296
Biblioteca responsable:
BR1.1
ABSTRACT
A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Terpenos
/
Leishmania braziliensis
/
Ciclohexenos
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Amino Alcoholes
/
Antiprotozoarios
Límite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2008
Tipo del documento:
Article
/
Project document
País de afiliación:
Brasil