Human antibody responses to Schistosoma mansoni: does antigen directed, isotype restriction result in the production of blocking antibodies?
Mem. Inst. Oswaldo Cruz
; 82(supl.4): 101-104, 1987.
Article
en En
| LILACS
| ID: lil-623671
Biblioteca responsable:
BR1.1
ABSTRACT
After treatment young Kenyan schoolchildren are highly susceptible to reinfection with Schistosoma mansoni. Older children and adults are resistant to reinfection. There is no evidence that this age related resistance is due to a slow development of protective immunological mechanisms, rather, it appears that young children are susceptible because of the presence of blocking antibodies which decline with age, thus allowing the expression of protective responses. Correlations between antibody responses to different stages of the parasite life-cycle suggest that, in young children, antigen directed, isotype restriction of the response against cross-reactive polysaccharide egg antigens results in an ineffectual, or even blocking antibody response to the schistosomulum.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Contexto en salud:
3_ND
Problema de salud:
3_helminthiasis
/
3_neglected_diseases
/
3_schistosomiasis
/
3_zoonosis
Asunto principal:
Schistosoma mansoni
/
Inmunoglobulina M
/
Anticuerpos Antihelmínticos
Límite:
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
1987
Tipo del documento:
Article
/
Congress and conference
País de afiliación:
Kenia
/
Reino Unido