Isolation, structural identification and cytotoxic activity of hexanic extract, cyperenoic acid, and jatrophone terpenes from Jatropha ribifolia roots
Rev. bras. farmacogn
; 23(3): 441-446, May-June 2013. ilus, graf, tab
Article
en En
| LILACS
| ID: lil-676275
Biblioteca responsable:
BR1.1
ABSTRACT
The cytotoxicity of a hexanic fraction produced from the ethanolic crude extract, obtained from Jatropha ribifolia (Pohl) Baill, Euphorbiaceae, roots was evaluated against ten human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460,786-O, UACC-62, K-562, U251) compared with doxorrubicine as positive control. Compounds jatrophone and cyperenoic acid were isolated from the hexanic extract and characterized by spectroscopic techniques (NMR of ¹H, 13C and IR). The in vitro antiproliferative activity of jatrophone showed selectivity in a concentration dependent way with Total Inhibition growth of glioma 0.57 µg mL-1 (U251), breast cancer 9.2 µg mL-1 (MCF-7), adriamycin-resistant ovarian cancer 0.96 µg mL-1 (NCI-ADR/RES), kidney 4.2 µg mL-1 (786-0), prostate cancer 8.4 µg mL-1 (PC-3), colon cancer 16.1 µg mL-1 (HT29) and leukemia 0.21 µg mL-1 (K-562).
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Rev. bras. farmacogn
Asunto de la revista:
FARMACIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil