Creatine supplementation in trained rats causes changes in myenteric neurons and intestinal wall morphometry
Biocell
; 37(2): 37-43, ago. 2013. graf
Article
en En
| LILACS
| ID: lil-708031
Biblioteca responsable:
AR40.1
ABSTRACT
Creatine is widely used by athletes as an ergogenic resource. The aim of this study was to evaluate the influence of creatine supplementation on the duodenum of rats submitted to physical training. The number and myenteric neuronal cell bodies as well mucosal and muscular tunic morphometry were evaluated. Control animals received a standard chow for 8 weeks, and the treated ones received the standard chow for 4 weeks and were later fed with the same chow but added with 2% creatine. Animals were divided in groups sedentary, sedentary supplemented with creatine, trained and trained supplemented with creatine. The training consisted in treadmill running for 8 weeks. Duodenal samples were either processed for whole mount preparations or for paraffin embedding and hematoxylin-eosin staining for histological and morpho metric studies of the mucosa, the muscular tunic and myenteric neurons. It was observed that neither creatine nor physical training alone promoted alterations in muscular tunic thickness, villus height or crypts depth, however, a reduction in these parameters was observed when both were associated. The number of myenteric neurons was unchanged, but the neuronal cell body area was reduced in trained animals but not when training and creatine was associated, suggesting a neuroprotector role of this substance.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Condicionamiento Físico Animal
/
Plexo Mientérico
/
Neuronas
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Biocell
Asunto de la revista:
Clulas
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil