Impacto clínico de un sistema de farmacovigilancia activa realizado por un farmacéutico en el reporte y subnotificación de reacciones adversas a medicamentos / Assessment of an active pharmacovigilance system carried out by a pharmacist
Rev. méd. Chile
; 142(8): 998-1005, ago. 2014. graf, tab
Article
en Es
| LILACS
| ID: lil-728348
Biblioteca responsable:
CL1.1
ABSTRACT
Background:
Despite the importance of notifying and preventing adverse drug reactions (ADRs), they are under reported and their consequences are not adequately evaluated.Aim:
To assess the impact of a pharmacovigilance system carried out by a pharmacist. Material andMethods:
In an internal medicine service, the spontaneous report of ADRs was compared blindly with an active pharmacovigilance system in which a pharmacist detected, monitored and prevented ADRs.Results:
A total of 1,196 patients was included. Of these 604 were hospitalized in intervened wards, where 50 suspected ADRs in 47 patients were reported. In non-intervened wards, only three ADRs were spontaneously reported. Therefore, the pharmacovigilance system significantly improved the detection and report of ADRs with a risk ratio of 15.4 (95% confidence intervals 4.8-49.1). Sixty six percent of ADRs were classified as severe. Antimicrobials were the main group of medications causing ADRs in 44% of reports. Forty three percent of ADRs were preventable and prolonged hospital stay by a mean of eight days.Conclusions:
An active pharmacovigilance system carried out by pharmacists improves the detection of ADRs and promotes its prevention.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Farmacéuticos
/
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
/
Farmacovigilancia
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Chile