Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus
Int. braz. j. urol
; 41(4): 642-654, July-Aug. 2015. tab, graf
Article
en En
| LILACS
| ID: lil-763058
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACTPurpose:
The aim of this study was to identify possible protein biomarkers and/or candidates for therapeutic targets in tissues of patients with SCCP, infected by HPV, applying one dimensional electrophoresis (1DE), followed by direct mass spectrometry (MS) analysis.Materials andMethods:
Tissues from 10 HPV positive patients with SCCP and from 10 patients with HPV negative non-tumorous penile foreskins were analyzed applying 1D electrophoresis, followed by analysis with direct mass spectrometry (MS).Results:
Sixty-three different proteins were identified in the first group and 50 in the second group. Recognition was possible for 28 proteins exclusively detected in Group 1 and 21 proteins presented only in Group 2.Conclusion:
Some proteins in the first group are directly involved in the development of other types of cancer, and therefore, suitable for analysis. Complement C3 protein is a strong candidate for evaluating SCCP patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Papillomaviridae
/
Neoplasias del Pene
/
Carcinoma de Células Escamosas
/
Infecciones por Papillomavirus
/
Proteómica
/
Proteínas de Neoplasias
Límite:
Humans
/
Male
Idioma:
En
Revista:
Int. braz. j. urol
Asunto de la revista:
UROLOGIA
Año:
2015
Tipo del documento:
Article
/
Project document
País de afiliación:
Brasil