DNA ploidy, Ki-67 and p53 as indicators of lymph node metastasis in early gastric carcinoma.
Anal Quant Cytol Histol
; 21(1): 85-8, 1999 Feb.
Article
en En
| MEDLINE
| ID: mdl-10068782
ABSTRACT
OBJECTIVE:
To perform flow cytometric and immunohistochemical analysis of early gastric carcinoma in order to investigate the clinical value of DNA ploidy, Ki-67 and p53 as indicators of lymph node metastasis. STUDYDESIGN:
We studied 108 cases of surgically resected early gastric carcinoma, which comprised 21 cases showing positive lymph node metastasis (group A) and 87 cases showing negative lymph node metastasis (group B).RESULTS:
Aneuploidy was seen in 16 cases (76.2%) in group A in contrast to 10 cases (11.5%) in group B (P = .0029). The mean value of the Ki-67 labeling rate in all cases was 21.9%, and 15 cases (79.0%) showed a Ki-67 labeling rate of more than 21.9% in group A, while they numbered 31 (37.4%) in group B (P = .0016). Cases with cell positive for p53 protein numbered 15 (75%) in group A, while they numbered 38 (46%) in group B (P = .0460).CONCLUSION:
DNA aneuploidy, a high labeling rate of Ki-67 and overexpression of p53 are all useful indicators of lymph node metastasis in patients with early gastric carcinoma.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Proteína p53 Supresora de Tumor
/
Antígeno Ki-67
/
Aneuploidia
/
Metástasis Linfática
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Anal Quant Cytol Histol
Asunto de la revista:
HISTOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Japón