-Skin eruption after the first dose of antitubercular quadri-therapy: consideration of pyrazinamide-. / Eruption après une première prise d'une quadrithérapie antituberculeuse: penser au pyrazinamide.

ABSTRACT

UNLABELLED We report a rash after the first dose of antituberculosis polytherapy which raises questions concerning procedures to be followed. CASE REPORT An 8-year-old child presented with a pruritic rash 1.5 hours after the first dose of isoniazide, rifampicine, pyrazinamide and ethambutol was simultaneously administered, which did not recur after successive re-administration of isoniazide and rifampicine. Pyrazinamide, which was re-administered last, induced a recurrence. Slower pyrazinamide re-administration allowed continuation of treatment. CONCLUSION: A protocol for re-administration of the four drugs is suggested.