[Is polycystic kidney disease a risk factor for neoplasm formation?]. / Czy wielotorbielowate zwyrodnienie nerek stanowi czynnik ryzyka zachorowania na nowotwór?

Our study aimed to elicit possible association between molecular and cytogenetic damage detected in lymphocytes of three members of family with polycystic kidney disease (41 and 19 years old females and in 9 years of age boy) and predictability to develop cancer or their susceptibility to environmental exposure. The DNA damage detected by Comet assay, chromosome aberrations and sisster chromatid exchanges were tested in lymphocytes and p21ras protein level in blood plasma. Lymphocytes of two persons showed higher level of cytogenetic damages and higher in responses to 0.5 Gy dose of radiation. We think it might be associated to specific aberration present in cells of these persons. A final conclusions can be taken when an application of FISH technique would be completed.