[Biochemical markers of gastric functioning]. / Marcatori biochimici di funzionalità gastrica.
Recenti Prog Med
; 90(6): 342-6, 1999 Jun.
Article
en It
| MEDLINE
| ID: mdl-10399476
ABSTRACT
The serum determination of pepsinogen A (PGA) and pepsinogen C (PGC) might indicate gastric mucosal inflammation and atrophy. Body gastric mucosa produces both PGA and PGC, while antral mucosa produces only PGC. Therefore, diseases involving mainly the antrum, such as H. pylori infection, are mainly indicated by the variations in serum PGC than in serum PGA. In agreement, when the antral mucosa is infected by the more virulent cagA positive H. pylori strains, which cause severe inflammation, serum PGC significantly increases. Another indirect indicator of gastric inflammation is polymorphonuclear (PMN) oxidative burst after the stimulation with water extracts from H. pylori culture this parameter is significantly increased in infected if compared to non-infected subjects. The higher oxidative burst response of peripheral PMN in infected patients, possibly consequent to the release of specific cytokines able to prime PMN towards H. pylori products, is unable to eliminate the infection, but it might concur in damaging the gastric mucosa.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estómago
Límite:
Humans
Idioma:
It
Revista:
Recenti Prog Med
Año:
1999
Tipo del documento:
Article