Isolation, cloning, and expression of a new murine zinc finger encoding gene.
Biochim Biophys Acta
; 1447(2-3): 278-83, 1999 Oct 28.
Article
en En
| MEDLINE
| ID: mdl-10542327
ABSTRACT
With the aim of identifying genes involved in cartilage differentiation, we have used a subtractive hybridization strategy with cDNAs from a chondrocytic cell line (MC615) and mRNAs from a mesenchymal precursor cell line (10T1/2). We have isolated a cDNA clone representing a novel mouse gene. The predicted 368-amino acid protein, designated ZF-12, contains four C(2)H(2)-type zinc finger motifs and one region homologous to the LeR domain, a finger-associated structural domain. ZF-12 mRNAs are expressed during embryonic development and in different organs in adult, including rib cartilage. These data suggest that ZF-12 might play an important role not only in cartilage differentiation, but also in basic cellular processes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dedos de Zinc
Límite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia