[Follow-up in lung transplant by the study of the pulmonary epithelial permeability and the pulmonary scintigraphies of ventilation and perfusion: preliminary results]. / Seguimiento del trasplante pulmonar mediante el estudio de la permeabilidad epitelial pulmonar y las gammagrafías pulmonares de ventilación y de perfusión: resultados preliminares.
Rev Esp Med Nucl
; 18(6): 408-15, 1999 Dec.
Article
en Es
| MEDLINE
| ID: mdl-10611566
ABSTRACT
INTRODUCTION:
Acute rejection is the most common complication in lung transplantation.OBJECTIVE:
This work aimed to assess the contribution of pulmonary clearance of radioaerosols and relative pulmonary perfusion to diagnose acute rejection in lung transplantation. MATERIAL ANDMETHOD:
We have designed a prospective study and present the results obtained for the preliminary phase. This work includes 5 patients who have received a lung transplantation and in whom 28 studies of pulmonary clearance of 99mTc-DTPA and relative pulmonary perfusion with 99mTc microspheres were performed. The pulmonary biopsy diagnosed 9 rejection episodes, 2 associated to CMV infection.RESULTS:
The mean radioaerosol clearance time increased when the follow-up was favorable and decreased in 6 of the 9 rejection episodes, including 2 associated to CMV infection. There was only one case with decreased mean clearance time that was not associated to rejection.CONCLUSIONS:
Calculating relative pulmonary perfusion can be useful in the follow-up of single lung transplantation but not in bipulmonary ones. Our results suggest that measuring 99mTc-DTPA clearance is useful to suspect a rejection episode.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pentetato de Tecnecio Tc 99m
/
Trasplante de Pulmón
/
Radiofármacos
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Mucosa Respiratoria
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
Es
Revista:
Rev Esp Med Nucl
Asunto de la revista:
MEDICINA NUCLEAR
Año:
1999
Tipo del documento:
Article