Antinociceptive substances from Incarvillea delavayi.
Phytochemistry
; 53(2): 253-6, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-10680179
ABSTRACT
Antinociceptive activities of an Incarvillea delavayi extract, as well as its constituents, 8-epideoxyloganic acid and delavayine A, were evaluated in the acetic acid induced writhing test in mice. An oral administration of the delavayi extract weakly decreased the number of writhings and stretchings in this test, in a dose-dependent manner. Furthermore, orally administered 8-epideoxyloganic acid showed weak antinociceptive activity, whereas administration by subcutaneous injection did not. However, subcutaneous injection of delavayine A, a novel monoterpene alkaloid, showed a more significant level of antinociceptive activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
/
Terpenos
/
Dimensión del Dolor
/
Extractos Vegetales
/
Monoterpenos
/
Alcaloides
/
Analgésicos
Límite:
Animals
Idioma:
En
Revista:
Phytochemistry
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón