Hepatocyte growth factor/scatter factor-induced intracellular signalling.
Int J Exp Pathol
; 81(1): 17-30, 2000 Feb.
Article
en En
| MEDLINE
| ID: mdl-10718861
ABSTRACT
Hepatocyte growth factor (HGF) identical to scatter factor (SF) is a glycoprotein involved in the development of a number of cellular phenotypes, including proliferation, mitogenesis, formation of branching tubules and, in the case of tumour cells, invasion and metastasis. This fascinating cytokine transduces its activities via its receptor encoded by the c-met oncogene, coupled to a number of transducers integrating the HGF/SF signal to the cytosol and the nucleus. The downstream transducers coupled to HGF/MET, most of which participate in overlapping pathways, determine the development of the cell's phenotype, which in most cell types is dual.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Factor de Crecimiento de Hepatocito
/
Proteínas Proto-Oncogénicas c-met
/
Hígado
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Exp Pathol
Asunto de la revista:
PATOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Reino Unido