[Role of neutrophils in regulation of immune responsiveness and reparative reactions of damaged tissue]. / Rol' neitrofilov v reguliatsii immunnoi reaktivnosti i reparativnykh reaktsii povrezhdennoi tkani.
Vestn Ross Akad Med Nauk
; (2): 14-9, 2000.
Article
en Ru
| MEDLINE
| ID: mdl-10723258
ABSTRACT
After both thermal and mechanical injuries, mice are shown to have depressed functions of phagocytes (primarily neutrophils), suppressed ability of an immune response to antigens and decreased skin inflammatory and reparative activities. It is suggested that a neutrophilic secretory defect and a decrease in the production of stimulating factors might be a cause of the above effects. After thermal and mechanical injuries, injection of neutrophilokin extracted from latex-activated neutrophilic supernatant into the mice promoted recovered phagocytic functional activity, higher humoral and cellular immune response and increased the rate of standard burn wound healing. Neutrophilokin also accelerated clavus formation in mice with mechanical injury. Thus, it can be concluded that neutrophils and their low-molecular secretory products play an important role in regulating immune and inflammatory reparative homeostasis in thermal and mechanical injuries.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Curación de Fractura
/
Inmunidad Celular
/
Neutrófilos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Ru
Revista:
Vestn Ross Akad Med Nauk
Asunto de la revista:
MEDICINA
Año:
2000
Tipo del documento:
Article