A new approach to phorbol by [4 + 3] oxyallyl cycloaddition and intramolecular Heck reaction.
Org Lett
; 1(3): 523-5, 1999 Aug 12.
Article
en En
| MEDLINE
| ID: mdl-10822592
ABSTRACT
[formula see text] A new synthetic strategy for a functionalized tricyclic core of phorbol has been developed by means of a [4 + 3] oxyallyl cycloaddition and subsequent intramolecular Heck reaction. The [4 + 3] oxyallyl cycloadduct 7 was chosen as the B-ring precursor of phorbol. Subsequent elaboration took advantage of its well-defined diastereofacial bias to afford the tricycle 5. This method should be of general value in the construction of 6,7- or 5,7-fused bicyclic systems.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Forboles
/
Compuestos Alílicos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos