A new strategy for cyclopentenone synthesis.
Org Lett
; 2(11): 1601-3, 2000 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-10841489
ABSTRACT
[reaction--see text] A new strategy for the synthesis of 2,3-disubstituted cyclopentenones emerges from two key reactions-the ruthenium-catalyzed three-component coupling of an equivalent of HBr, an alkyne, and a vinyl ketone and the Ni-Cr Barbier type reaction. As a result, these important structures are readily accessed from an alkyne and a vinyl ketone (which derive directly from carboxylic acids). Syntheses of tetrahydrodicranenone B and rosaprostol illustrate the new strategy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciclopentanos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos