Potentiation of warfarin anticoagulation associated with topical methyl salicylate.
Ann Pharmacother
; 34(6): 729-33, 2000 Jun.
Article
en En
| MEDLINE
| ID: mdl-10860133
ABSTRACT
OBJECTIVE:
To report a case of international normalized ratio (INR) elevation resulting from the administration of topical methyl salicylate in a patient whose INR was previously stable while she received warfarin anticoagulation. CASESUMMARY:
A 22-year-old white woman presented with an INR of 12.2 after applying a topical pain-relieving gel to her knees daily for eight days. The potentiation of the warfarin anticoagulation was attributed to the low-dose methyl salicylate contained in the product.DISCUSSION:
Methyl salicylate is systemically absorbed through the skin in measurable amounts, and may increase warfarin action by affecting vitamin K metabolism or by displacing warfarin from protein-binding sites. While several investigators have reported this interaction with use of high-dose methyl salicylate, this case indicates that a significant interaction can occur with the use of lower topical doses of methyl salicylate as well.CONCLUSIONS:
Healthcare providers and patients taking warfarin must be aware of the potential hazard of using topical methyl salicylate in combination with warfarin.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Warfarina
/
Salicilatos
/
Relación Normalizada Internacional
/
Fijadores
/
Anticoagulantes
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Ann Pharmacother
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos