Correlation of telomere lengths in normal and cancers tissue in the large bowel.
Cancer Lett
; 158(2): 179-84, 2000 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-10960768
ABSTRACT
The hypothesis that telomeres in colorectal cancer cells exhibit age-related shortening, as in normal cells of the colorectal epithelium, was tested with samples of non-cancerous mucosa and cancer tissue from 124 patients (aged 29-97 years). Shortening with aging could be demonstrated for both normal and cancer tissues; regression analysis showed rates for length reduction of 44 and 50 base pair/year, respectively. Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Telómero
/
Intestino Grueso
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Infant
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Male
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Middle aged
Idioma:
En
Revista:
Cancer Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón