The biology of multiple myeloma.
J Cancer Res Clin Oncol
; 126(8): 441-7, 2000 Aug.
Article
en En
| MEDLINE
| ID: mdl-10961386
ABSTRACT
Multiple myeloma (MM) is a B-cell malignancy originating from pre-switched, follicle center B-lymphocytes which differentiate to plasma cells accumulating in the bone marrow. MM cells are characterized by a profound genetic instability resulting in a complex set of numerical and structural chromosomal abnormalities. Among these abnormalities, translocations involving 14q32, the immunoglobulin heavy-chain locus, are the most frequent aberrations, but translocation partners are remarkably heterogeneous. Chromosome 13q14 may harbor a critical tumor suppressor gene since MM patients with deletion of 13q14 experience short overall survival after conventional-dose and high-dose chemotherapy. Bone marrow stroma cells support growth and survival of MM cells, which in turn influence the bone marrow microenvironment. This is particularly evident by the markedly increased bone marrow vascularization observed in most patients with active MM.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_cardiovascular_diseases
/
6_congenital_chromosomal_anomalies
/
6_lymphomas_multiple_myeloma
Asunto principal:
Mieloma Múltiple
Límite:
Humans
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Austria