The pachytene checkpoint.
Trends Genet
; 16(9): 395-403, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-10973068
ABSTRACT
The pachytene checkpoint prevents meiotic nuclear division in cells that fail to complete meiotic recombination and chromosome synapsis. This control mechanism prevents chromosome missegregation that would lead to the production of aneuploid gametes. The pachytene checkpoint requires a subset of proteins that function in the mitotic DNA damage checkpoint. In budding yeast, the pachytene checkpoint also requires meiosis-specific chromosomal proteins and, unexpectedly, proteins concentrated in the nucleolus. Progress has been made in identifying components of the cell-cycle machinery that are impacted by the checkpoint.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciclo Celular
/
Cromosomas
/
Meiosis
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos