Human T cell leukemia virus type II increases telomerase activity in uninfected CD34+ hematopoietic progenitor cells.
J Hematother Stem Cell Res
; 9(4): 481-7, 2000 Aug.
Article
en En
| MEDLINE
| ID: mdl-10982246
ABSTRACT
The aging process of long-term self-renewing hematopoietic stem/progenitor cells is not yet completely understood and recent studies on antiapoptotic cell pathways have demonstrated a close linkage between telomerase activation and Bcl-2 deregulation in human cancer cells. The present work shows that human T cell leukemia virus type II (HTLV-II) Mo virions that have originated from the T cell line (C344), but not from the B cell line (BJAB), are critically involved in mediating survival and growth effects on hematopoietic precursors (represented by both the TF-1 CD34+ cell line and by peripheral blood-derived CD34+ cells) through the maintenance or enhancement of telomerase activity and the induction of bcl-2 expression. In addition, using an interleukin-3-dependent TF-1 cell line, it was demonstrated that IL-3 deprivation was sufficient to influence the levels of telomerase activity and Bcl-2 expression in CD34+ cells. Taken together, these findings suggest that, in appropriate conditions, extended hematopoietic progenitor cell survival and proliferation following HTLV-II exposure depends on a synergistic interaction between up-regulation of Bcl-2 and activation of telomerase activity.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Madre Hematopoyéticas
/
Virus Linfotrópico T Tipo 2 Humano
/
Telomerasa
/
Antígenos CD34
Límite:
Humans
Idioma:
En
Revista:
J Hematother Stem Cell Res
Asunto de la revista:
HEMATOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia