Combinatorial roles of the nuclear receptor corepressor in transcription and development.
Cell
; 102(6): 753-63, 2000 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-11030619
ABSTRACT
Transcriptional repression plays crucial roles in diverse aspects of metazoan development, implying critical regulatory roles for corepressors such as N-CoR and SMRT. Altered patterns of transcription in tissues and cells derived from N-CoR gene-deleted mice and the resulting block at specific points in CNS, erythrocyte, and thymocyte development indicated that N-CoR was a required component of short-term active repression by nuclear receptors and MAD and of a subset of long-term repression events mediated by REST/NRSF. Unexpectedly, N-CoR and a specific deacetylase were also required for transcriptional activation of one class of retinoic acid response element. Together, these findings suggest that specific combinations of corepressors and histone deacetylases mediate the gene-specific actions of DNA-bound repressors in development of multiple organ systems.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Transcripción Genética
/
Proteínas Nucleares
/
Regulación del Desarrollo de la Expresión Génica
Límite:
Animals
Idioma:
En
Revista:
Cell
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos