Redefining medical treatment in the management of unstable angina.
Am J Med
; 108(1): 41-53, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-11059440
ABSTRACT
In 1994, the Agency for Health Care Policy and Research sponsored the development of guidelines for diagnosing and managing patients with unstable angina. Since their publication, several important developments have occurred. The prognostic value of biochemical assays for cardiac-specific troponins T and I have been shown in many studies. The possible role for C-reactive protein in determining prognosis deserves further investigation. Substantial clinical benefits have been obtained with intravenous inhibitors of the platelet glycoprotein (GP) IIb-IIIa receptor (abciximab, eptifibatide, tirofiban) and with one of the low-molecular-weight heparins (enoxaparin). The therapeutic potential of other low-molecular-weight heparins, direct thrombin inhibitors, and oral GP IIb-IIIa inhibitors remains to be clarified. On the basis of this evidence, consideration should be given to measuring serum levels of a cardiac troponin (either T or I) and using intravenous GP IIb-IIIa inhibitors and low-molecular-weight heparin in the standard management of patients with unstable angina.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tirosina
/
Proteína C-Reactiva
/
Inhibidores de Agregación Plaquetaria
/
Heparina de Bajo-Peso-Molecular
/
Complejo GPIIb-IIIa de Glicoproteína Plaquetaria
/
Troponina I
/
Troponina T
/
Angina Inestable
/
Infarto del Miocardio
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Guideline
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Med
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos