Voltammetric analysis of certain 4-quinolones in pharmaceuticals and biological fluids.
J Pharm Biomed Anal
; 24(2): 211-8, 2000 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-11130200
ABSTRACT
The voltammetric behaviour of Enrofloxacin (I), Sparfloxacin (II) and Fleroxacin (III) was studied using direct current (DCt), differential pulse (DPP) and alternating current (ACt). All the drugs manifest cathodic waves in Britton Robinson buffer over the pH range of 4.0-11.98. The waves were characterized as being irreversible, diffusion-controlled with limited adsorption properties. The diffusion current concentration relationships were found to be rectilinear over the ranges 4 x 10(-5) x 10(-4) M, 1 x 10(-5)-2 x 10(-4) M, 1 x 10(-5)-4 x 10(-4) M using DCt mode for I, II and III, respectively and 1 x 10(-6)-4 x 10(-5) M, 1 x 10(-6)-1 x 10(-4) M, and 2 x 10(-6)-8 x 10(-5) M, using DPP mode for I, II and III respectively, with minimum detectability (S/N = 3) of 1 x 10(-7) M for I, II and 2 x 10(-7) M for III. The proposed method was successfully applied to the determination of the studied compounds either per se or in formulations and biological fluids. The results obtained were concordant to those given using reference methods.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fleroxacino
/
Quinolonas
/
Fluoroquinolonas
/
Electroquímica
/
Antiinfecciosos
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
2000
Tipo del documento:
Article
País de afiliación:
Egipto