Fibrosis and hypertensive heart disease.
Curr Opin Cardiol
; 15(4): 264-72, 2000 Jul.
Article
en En
| MEDLINE
| ID: mdl-11139090
ABSTRACT
The normal myocardium is composed of a variety of cells cardiac myocytes and noncardiomyocytes, which include endothelial and vascular smooth muscle cells and fibroblasts. Hypertensive heart disease involves a structural remodeling of muscular and nonmuscular compartments. It is not the quantity but rather the quality of myocardium that accounts for pathologic hypertrophy and predisposes to ventricular dysfunction and arrhythmias, which, in turn, confer increased risk of adverse cardiovascular events. Herein, factors regulating growth of these compartments are reviewed and in particular signals involved in promoting adverse remodeling of intramyocardial coronary arteries and arterioles by fibrous tissue.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cardiomegalia
/
Fibrosis Endomiocárdica
/
Hipertensión
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cardiol
Asunto de la revista:
CARDIOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos