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Phosphodiesterase 4 isoenzyme inhibitory activity of 3-phenylxanthines and 4-pheny.
Suzuki, H; Sawanishi, H; Yamamoto, K; Yokogawa, K; Miyamoto, K.
Afiliación
  • Suzuki H; Department of Synthetic Chemistry, Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan. h-suzuki@hokuriku-u.ac.jp
Chem Pharm Bull (Tokyo) ; 49(2): 188-91, 2001 Feb.
Article en En | MEDLINE | ID: mdl-11217107
ABSTRACT
On the basis of our study on the structure-activity relationships of 1,3,7-alkylxanthines and condensed-purines on cAMP-phosphodiesterase 4 (PDE 4) isoenzyme inhibitor, we investigated the synthesis and the inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-purine derivatives. Xanthines and condensed-purines with the phenyl group exhibited potent and selective PDE 4 inhibitory activity.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Purinas / Xantinas / 3',5'-AMP Cíclico Fosfodiesterasas / Inhibidores Enzimáticos Límite: Animals Idioma: En Revista: Chem Pharm Bull (Tokyo) Año: 2001 Tipo del documento: Article País de afiliación: Japón
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Purinas / Xantinas / 3',5'-AMP Cíclico Fosfodiesterasas / Inhibidores Enzimáticos Límite: Animals Idioma: En Revista: Chem Pharm Bull (Tokyo) Año: 2001 Tipo del documento: Article País de afiliación: Japón