Identification of new repeating motifs in titin.
Proteins
; 43(2): 145-9, 2001 May 01.
Article
en En
| MEDLINE
| ID: mdl-11276084
ABSTRACT
Repeating motifs of 26-28 amino acids have been identified in the PEVK region of the giant elastic protein titin. These motifs, termed PPAK for the four amino acids that often constitute the beginning of the motif, occur 60 times in human soleus titin. PPAK motifs occur in groups of 2-12 that are separated by regions rich in glutamic acid (approximately 45%) and termed polyE segments. The fluctuation of the net charge between the PPAK and polyE regions suggests ionic interactions between these segments and their involvement in the elastic function of titin. Proteins 2001;43145-149.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas
/
Proteínas Musculares
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Proteins
Asunto de la revista:
BIOQUIMICA
Año:
2001
Tipo del documento:
Article