[Rapid effect of glucocorticoid on excitatory postsynaptic potential of B cells in bullfrog paravertebral ganglia].
Sheng Li Xue Bao
; 50(6): 679-82, 1998 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-11367681
ABSTRACT
In the present study, the rapid effect of hydrocortisone 21-hemisuccinate (F-suc) on the amplitude of f-EPSP of B cells in isolated bullfrog sympathetic ganglia was examined with the use of intracellular recording technique. It was found that the amplitude of f-EPSP of B cells was decreased by F-suc, with a latency less than 3 min after the beginning of perfusion of F-suc. The inhibition of F-suc was concentration-dependent and could be blocked by the antagonist of intracellular glucocorticoid receptor RU38486, but not by the protein synthesis inhibitor actidione. These findings suggest that the inhibition of f-EPSP of B cells by F-suc is probably mediated through a nongenomic mechanism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hidrocortisona
/
Potenciales Postsinápticos Excitadores
/
Ganglios Parasimpáticos
Límite:
Animals
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
1998
Tipo del documento:
Article