Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of T-cell development.
Pediatr Hematol Oncol
; 18(4): 267-72, 2001 Jun.
Article
en En
| MEDLINE
| ID: mdl-11400651
ABSTRACT
The authors report on a 14-year-old boy who developed T-cell acute lymphoblastic leukemia (FABL1) displaying 4 immunophenotypically distinct leukemic cell populations by 3-color immunofluorescence staining. Cytogenetic analysis at diagnosis showed 46,XY,add(4)(p16)[12]/46,XY[2]. A single rearrangement of the T-cell antigen receptor beta- and gamma-chain genes in these cells indicated monoclonality of the leukemic cells. These findings suggest that leukemic blast cells of monoclonal origin in this case were divided into 4 immunophenotypic populations, representing various stages of differentiation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia-Linfoma de Células T del Adulto
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Límite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Hematol Oncol
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón