Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase.
Br J Cancer
; 84(12): 1677-80, 2001 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-11401323
ABSTRACT
The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Uridina Fosforilasa
/
Neoplasias de la Mama
/
Transfección
/
Fluorouracilo
/
Antimetabolitos Antineoplásicos
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Br J Cancer
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia