Your browser doesn't support javascript.
loading
A nine-year experience of immunoprophylaxis against hepatitis B virus infection in children with cancer: results from a single institution in Poland.
Styczynski, J; Wysocki, M; Koltan, S; Kurylak, A.
Afiliación
  • Styczynski J; Department of Paediatric Haematology and Oncology, Medical University, Bydgoszcz, Poland. jan_styczynski@kki.net.pl
J Hosp Infect ; 48(4): 298-303, 2001 Aug.
Article en En | MEDLINE | ID: mdl-11461131
The results of a nine-year study of immunoprophylaxis against HBV infection in children with cancer during anticancer therapy are presented. Three hundred and fifty-three children entered the study. The preventive strategy involved three different patterns of passive and active prophylaxis. Specific anti-HBV immunoprophylaxis introduced simultaneously with anticancer therapy resulted in protection of 95.2% of children; 62% of patients produced antibodies. Long-term follow-up confirmed stable protection. Better results were obtained in children who received the last dose of vaccine after chemotherapy. The overall infection rate was 5.4% (19/353). Thirteen (68.4%) of the 19 infections occurred in patients who had not received hepatitis B immunoglobulin at the beginning of anticancer therapy. Children vaccinated before chemotherapy (during a neonatal vaccination programme) showed continuous protection after one dose of vaccine in 94% cases. In three cases, both HBsAg and anti-HBs was observed. A preventive strategy for viral hepatitis in children with cancer that includes passive and active HBV immunoprophylaxis from the beginning of chemotherapy is effective.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: Inmunoglobulinas / Inmunización Pasiva / Huésped Inmunocomprometido / Hepatitis B / Neoplasias Límite: Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Hosp Infect Año: 2001 Tipo del documento: Article País de afiliación: Polonia
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: Inmunoglobulinas / Inmunización Pasiva / Huésped Inmunocomprometido / Hepatitis B / Neoplasias Límite: Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Hosp Infect Año: 2001 Tipo del documento: Article País de afiliación: Polonia
...