Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.
Proc Natl Acad Sci U S A
; 98(17): 9907-12, 2001 Aug 14.
Article
en En
| MEDLINE
| ID: mdl-11481456
ABSTRACT
Neurogenic genes in the Notch receptor-mediated signaling pathway play important roles in neuronal cell fate specification as well as neuronal differentiation. The Drosophila neuralized gene is one of the neurogenic genes. We have cloned a mouse homolog of Drosophila neuralized, m-neu1, and found that the m-neu1 transcript is expressed in differentiated neurons. Mice deficient for m-neu1 are viable and morphologically normal, but exhibit specific defects in olfactory discrimination and hypersensitivity to ethanol. These findings reveal an essential role of m-neu1 in ensuring proper processing of certain information in the adult brain.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Olfato
/
Proteínas de Drosophila
/
Ubiquitina-Proteína Ligasas
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Discriminación en Psicología
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Etanol
/
Ligasas
/
Trastornos del Olfato
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos