Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy.
J Virol
; 75(17): 8195-202, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11483765
ABSTRACT
Production of the C-X-C chemokines interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-alpha) in macrophages is stimulated by exposure to human immunodeficiency virus type 1 (HIV-1). We have demonstrated previously that GRO-alpha then stimulates HIV-1 replication in both T lymphocytes and macrophages. Here we demonstrate that IL-8 also stimulates HIV-1 replication in macrophages and T lymphocytes. We further show that increased levels of IL-8 are present in the lymphoid tissue of patients with AIDS. In addition, we demonstrate that compounds which inhibit the actions of IL-8 and GRO-alpha via their receptors, CXCR1 and CXCR2, also inhibit HIV-1 replication in both T lymphocytes and macrophages, indicating potential therapeutic uses for these compounds in HIV-1 infection and AIDS.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Interleucina-8
/
Síndrome de Inmunodeficiencia Adquirida
/
VIH-1
/
Quimiocinas CXC
/
Péptidos y Proteínas de Señalización Intercelular
/
Macrófagos
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos