[Gene c-Fos expression in brain of rats resistant and predisposed to emotional stress after intraperitoneal injection of the ACTH(4-10)analog--semax]. / Ekspressiia gena c-Fos v mozge u krys s razlichnoi ustoichivost'iu k émotsional'nomu stressu v usloviiakh vnutribpiushinnogo vvedeniia analoga AKTG(4-10)--semaksa.
Zh Vyssh Nerv Deiat Im I P Pavlova
; 51(2): 220-7, 2001.
Article
en Ru
| MEDLINE
| ID: mdl-11548604
ABSTRACT
The effect of the ACTH(4-10) analog Semax on immediate early gene c-Fos expression was studied in Wistar rats with high and low resistance to emotional stress under the usual conditions and during psychoemotional loading. Fos-immunoreactive cells in the were counted automatically with the help of a computer. It was shown that under the usual conditions the intraperitoneal Semax injection induced immediate early gene c-Fos expression in the lateral septal region in rats predisposed to emotional stress and in the paraventricular hypothalamus in rats of both groups. Preliminary Semax injection decreased the stress-induced c-Fos expression in the paraventricular hypothalamus and medial septum in rats predisposed to emotional stress and tended to reduce the number of stress-induced c-Fos-immunopositive cells in the lateral septum and basolateral amygdala in both groups of animals. The obtained data suggest that Semax differently affects the immediate early c-Fos gene expression in the brain of rats resistant and predisposed to emotional stress and this effect reflects the antistressor properties of the regulatory peptide.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Estrés Psicológico
/
Encéfalo
/
Regulación de la Expresión Génica
/
Genes fos
/
Hormona Adrenocorticotrópica
/
Fármacos Neuroprotectores
Límite:
Animals
Idioma:
Ru
Revista:
Zh Vyssh Nerv Deiat Im I P Pavlova
Asunto de la revista:
NEUROLOGIA
Año:
2001
Tipo del documento:
Article