Nasal ciliary function and ultrastructure in Down syndrome.
Laryngoscope
; 111(7): 1227-30, 2001 Jul.
Article
en En
| MEDLINE
| ID: mdl-11568545
ABSTRACT
OBJECTIVES/HYPOTHESIS:
To investigate the in vivo nasal ciliary beat and the ciliary ultrastructure in Down syndrome because, although in this condition an increased susceptibility to respiratory tract infections has been reported by several authors, the nature of this phenomenon is not fully understood. STUDYDESIGN:
Experimental study of 18 subjects with Down syndrome and 18 healthy control subjects.METHODS:
Ciliary beat frequency (CBF) was measured on samples of ciliated epithelium obtained from the inferior nasal turbinate; a further brushing for ultrastructural analysis was performed only in subjects showing a CBF reduction or a ciliary movement alteration.RESULTS:
The mean CBF in the group with Down syndrome was 7 +/- 2.82 Hz, and in the control subjects it was 10.94 +/- 0.65 Hz. In the same 66.6% of subjects with Down syndrome, we observed a fibrillatory movement of cilia and no metachronicity was present. Moreover, in 14 subjects with Down syndrome as hyperproduction of mucus was present. Ultrastructural evaluation at transmission election microscopy instead revealed a normal architecture of cilia.CONCLUSION:
We attribute the nature of the mucociliary defect in Down syndrome to recurrent respiratory tract infections causing changes in mucus properties as in rheological parameters and not to a primitive defect of cilia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cornetes Nasales
/
Depuración Mucociliar
/
Cilios
/
Síndrome de Down
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Idioma:
En
Revista:
Laryngoscope
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia