Idiotype and anti-idiotype specific T cell responses on transplantation with hybridomas reactive to viral hemagglutinin and human tumor antigen.
Immunol Lett
; 80(2): 81-7, 2002 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-11750038
ABSTRACT
B cell hybridomas expressing class I and II MHC molecules and producing antibodies directed against hemagglutinin protein of Rinderpest virus and human Mucin-1 have been used as surrogate B cells to study T cell responses against the antigens. The observed CTL and lymphoproliferative response indicates that anti-idiotypic B cells termed Jerne cells stimulate both T helper and T cytotoxic cells by virtue of their ability to present recycled or regurgitated peptido-mimics of antigen to T helper cells through class II MHC and de novo synthesized peptido-mimics of antigens to CTLs. Thus, T cell memory response can be perpetuated by anti-idiotypic Jerne B cells and these findings lend support to the earlier proposed relay hypothesis for perpetuation of immunological memory (IM).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T Citotóxicos
/
Linfocitos T Colaboradores-Inductores
/
Hemaglutininas Virales
/
Hibridomas
/
Epítopos
/
Antígenos de Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Lett
Año:
2002
Tipo del documento:
Article
País de afiliación:
India