Pathogenesis of defective retroviruses.
Dev Biol (Basel)
; 106: 201-8; discussion 209-10, 253-63, 2001.
Article
en En
| MEDLINE
| ID: mdl-11761232
ABSTRACT
Concerns about the presence of contaminating defective retroviruses in cells used for vaccine preparations have been raised. These concerns mainly reflect the fact that (i) most species harbour several copies of endogenous defective and/or non-defective retroviral sequences in their genome; (ii) these sequences have frequently been found to participate in recombination events giving rise to novel viral entities; and (iii) several strains of defective retroviruses have been shown to be pathogenic. Here, a brief description of the main features of defective retroviruses is provided. In addition, the characteristics and plasticity of defective retroviruses are illustrated with a defective retrovirus inducing a mouse disease, murine AIDS (MAIDS).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Retroviridae
/
Virus Defectuosos
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Dev Biol (Basel)
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Canadá