Choosing new adsorbents for endogenous ultrapure infusion fluid: performances, safety and flow distribution.
Int J Artif Organs
; 24(11): 765-76, 2001 Nov.
Article
en En
| MEDLINE
| ID: mdl-11797846
ABSTRACT
Adsorption may notably contribute to the removal of uremic toxins and to the efficiency of hemodialysis. We examined different uncoated stationary matrixes, charcoals and synthetic resins to establish their adsorptive capacities in relation to low (urea, creatinine) and high molecular weight (beta2-microglobulin, myoglobin) compounds in in vitro conditions (steady state and flow-through) using isotonic solutions or uremic ultrafiltrate. Trace metal, particle release analyses and scanning electron microscopy of different adsorbents were performed. Dynamic flow-distribution studies were made using 99Technetium and analysing the different regions of interest by single head gamma-camera. We show that adsorbents may differ greatly as to their adsorptive capacity depending on flow rate, nature, and total mass of the compounds to be removed from the ultrafiltrate. These studies suggest a methodological approach for screening stationary matrixes for possible application in hemodialysis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Soluciones para Hemodiálisis
/
Diálisis Renal
Límite:
Humans
Idioma:
En
Revista:
Int J Artif Organs
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia