Regiocontrolled synthesis of the trimeric quinone framework of conocurvone.
Org Lett
; 4(4): 521-4, 2002 Feb 21.
Article
en En
| MEDLINE
| ID: mdl-11843581
ABSTRACT
[reaction see text] The trimeric quinone framework of conocurvone is crucial for its potent anti-HIV activity. A new synthesis of trimeric quinones based on stepwise substitution of the halogens in 2,3-dihaloquinones by hydroxyquinone anions is described. Chlorinated biquinones are key intermediates that undergo regiospecific substitution reactions to yield trimeric quinone monomethyl ethers.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinonas
/
Naftoquinonas
/
Fármacos Anti-VIH
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos