Synthesis and cholinesterase activity of phenylcarbamates related to Rivastigmine, a therapeutic agent for Alzheimer's disease.
Eur J Med Chem
; 37(2): 91-109, 2002 Feb.
Article
en En
| MEDLINE
| ID: mdl-11858843
ABSTRACT
In order to develop new cholinesterase agents effective against Alzheimer's disease (AD) we synthesized some phenylcarbamates structurally related to Rivastigmine and evaluated their in vitro and in vivo biological activity. Among the compounds which displayed the most significant in vitro activity, 1-[1-(3-dimethylcarbamoyloxyphenyl)ethyl]piperidine (31b), in addition to a simple and cheaper synthesis, showed lower toxicity and very similar therapeutic index in comparison with Rivastigmine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carbamatos
/
Inhibidores de la Colinesterasa
/
Fenilcarbamatos
/
Enfermedad de Alzheimer
Límite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Año:
2002
Tipo del documento:
Article
País de afiliación:
Italia