The antiviral dynamin family member, MxA, tubulates lipids and localizes to the smooth endoplasmic reticulum.
J Biol Chem
; 277(24): 21829-35, 2002 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-11916975
ABSTRACT
Mx proteins are induced by type I interferon and inhibit a broad range of viruses by undefined mechanisms. They are included within the dynamin family of large GTPases, which are involved in vesicle trafficking and share common biophysical features. These properties include the propensity to self-assemble, an affinity for lipids, and the ability to tubulate membranes. In this report we establish that human MxA, despite sharing only 30% homology with conventional dynamin, possesses many of these properties. We demonstrate for the first time that MxA self-assembles into rings that tubulate lipids in vitro, and associates with a specific membrane compartment in cells, the smooth endoplasmic reticulum.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Biosíntesis de Proteínas
/
Proteínas
/
Proteínas de Unión al GTP
/
Retículo Endoplásmico
Límite:
Humans
Idioma:
En
Revista:
J Biol Chem
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos