Germline stem cells anchored by adherens junctions in the Drosophila ovary niches.
Science
; 296(5574): 1855-7, 2002 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-12052957
ABSTRACT
How stem cells are recruited to and maintained in their niches is crucial to understanding their regulation and use in regenerative medicine. Here, we demonstrate that DE-cadherin-mediated cell adhesion is required for anchoring germline stem cells (GSCs) in their niches in the Drosophila ovary. Two major components of this adhesion process, DE-cadherin and Armadillo/beta-catenin, accumulate at high levels in the junctions between GSCs and cap cells, one of the niche components. Removal of these proteins from GSCs results in stem cell loss. Furthermore, DE-cadherin is required for recruiting GSCs to their niche. Our study demonstrates that anchorage of GSCs in their niche by DE-cadherin-mediated adhesion is important for stem cell maintenance and function.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oocitos
/
Células Madre
/
Cadherinas
/
Transactivadores
/
Uniones Adherentes
/
Proteínas de Drosophila
/
Drosophila
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos