[Soluble adhesion molecules in antiphospholipid syndrome associated with systemic lupus erythematosus and in primary antiphospholipid syndrome]. / Rastvorimye molekuly adgezii pri antifosfolipidnom sindrome, sviazannom s sisemnoi krasnoi volchankoi, i pervichnom antifosfolipidnom sindrome.
Ter Arkh
; 74(5): 23-7, 2002.
Article
en Ru
| MEDLINE
| ID: mdl-12087900
ABSTRACT
AIM:
To evaluate clinical implications of measurements of the level of soluble cell molecules of adhesion (sCMA) in systemic lupus erythematosus (SLE) with antiphospholipid syndrome (APS) and primary APS (PAPS). MATERIAL ANDMETHODS:
Serum levels of sP-selectine, sE-selectine, sVCAM-1 were determined with enzyme immunoassay (R&D, USA) in 23 SLE with APS, 15 SLE patients free of APS and 19 patients with PAPS.RESULTS:
Mean levels of sE-selectine and sVCAM-1 in SLE patients with APS, PAPS and SLE was higher than in donors. Elevated mean levels of sP-selectine were observed only in SLE patients free of APS. These patients also showed a correlation between sVCAM-1 level and the disease activity (p < 0.01).CONCLUSION:
The development of immunopathological process in APS is associated with increased concentration of sCMA.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Moléculas de Adhesión Celular
/
Síndrome Antifosfolípido
/
Lupus Eritematoso Sistémico
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Ter Arkh
Año:
2002
Tipo del documento:
Article