QTc interval prolongation and QTc dispersion in children and adolescents with type 1 diabetes.
J Pediatr
; 141(1): 59-63, 2002 Jul.
Article
en En
| MEDLINE
| ID: mdl-12091852
ABSTRACT
OBJECTIVES:
To evaluate whether QT interval, QT interval corrected for heart rate (QTc), and QTc dispersion changes are already present in children and adolescents with diabetes. STUDYDESIGN:
QT interval, QTc, and QTc dispersion were measured on a 12-lead surface electrocardiogram in 60 children and adolescents with stable type 1 diabetes and in 63 sex- and age-matched control subjects. Differences were evaluated by using the Kolmogorov-Smirnov Z test. The number of patients with QTc > 440 ms was compared in the two groups. The possible influence of age, sex, diabetes duration, and glycosylated hemoglobin (HbA(1c)) was examined by using Spearman correlation analysis.RESULTS:
Diabetic children had significantly longer QTc intervals and a significantly larger QTc dispersion. The number of individuals with a QTc >440 ms was significantly higher in the diabetic group (14/60) than in the control group (2/63). The effect of age on R-R interval and QTc dispersion in healthy children was less pronounced in children with diabetes. HbA(1C) values did not significantly correlate with any of the parameters.CONCLUSIONS:
QTc prolongation and a larger QTc dispersion are already present in a significant proportion of children and adolescents with diabetes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades del Sistema Nervioso Autónomo
/
Síndrome de QT Prolongado
/
Diabetes Mellitus Tipo 1
/
Neuropatías Diabéticas
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Pediatr
Año:
2002
Tipo del documento:
Article
País de afiliación:
Bélgica