Immune reconstitution pneumonitis following Pneumocystis carinii pneumonia in HIV-infected subjects.
HIV Med
; 3(3): 207-11, 2002 Jul.
Article
en En
| MEDLINE
| ID: mdl-12139660
ABSTRACT
An HIV-infected man presented with a pneumonic illness following an episode of treated Pneumocystis carinii pneumonia (PCP). He had a rise in his CD4 count from 4 to 125 cells/microL on antiretroviral therapy prior to the onset of the second respiratory event. Bronchoalveolar lavage (BAL) revealed no pathogen, although a CD4 lymphocytosis in addition to a highly unusual population of rapidly proliferating CD8 cells was demonstrated. Following 2 weeks of steroid and anti-pneumocystis therapy, a repeat bronchoscopy demonstrated that the expression of these markers had returned to low values. This second respiratory illness, which may have arisen as a consequence of the regenerating immune response reacting to residual P. carinii antigen in the lung, is apparently not rare. When we reviewed our case notes, five further individuals were identified that had started antiretroviral therapy following an episode of PCP and subsequently developed a self-limiting pneumonitis for which no pathogen was identified on bronchoscopy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neumonía
/
Neumonía por Pneumocystis
/
Infecciones Oportunistas Relacionadas con el SIDA
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
HIV Med
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2002
Tipo del documento:
Article
País de afiliación:
Reino Unido