Sordarin oxazepine derivatives as potent antifungal agents.
Bioorg Med Chem Lett
; 12(19): 2757-60, 2002 Oct 07.
Article
en En
| MEDLINE
| ID: mdl-12217370
ABSTRACT
The synthesis and biological activity of sordarin oxazepine derivatives are described. The key step features a regioselective oxidation of an unprotected triol followed by double reductive amination to afford the ring-closed products. The spectrum of antifungal activity for these novel derivatives includes coverage of Candida albicans, Candida glabrata, and Cryptococcus neoformans.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxazepinas
/
Hongos
/
Antifúngicos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos