Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth.
J Neurochem
; 82(6): 1566-9, 2002 Sep.
Article
en En
| MEDLINE
| ID: mdl-12354307
ABSTRACT
A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neuritas
/
Glicoproteína Asociada a Mielina
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neurochem
Año:
2002
Tipo del documento:
Article
País de afiliación:
Canadá