4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1.
J Immunol
; 169(9): 4882-8, 2002 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-12391199
ABSTRACT
4-1BB, a T cell costimulatory receptor, prolongs CD8(+) T cell survival. In these studies, 4-1BB stimulation was shown to increase expression of the antiapoptotic genes bcl-x(L) and bfl-1 via 4-1BB-mediated NF-kappaB activation. This signaling pathway was specifically inhibited by PDTC and was different from the pathways that enhanced CD8(+) T cell proliferation. The results suggest a role for the antiapoptotic activities of Bcl-x(L) and Bfl-1 proteins in 4-1BB-mediated CD8(+) T cell survival in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Factor de Crecimiento Nervioso
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Apoptosis
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Receptores del Factor de Necrosis Tumoral
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Linfocitos T CD8-positivos
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Proteínas Proto-Oncogénicas c-bcl-2
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Quinasa 1 de Quinasa de Quinasa MAP
Idioma:
En
Revista:
J Immunol
Año:
2002
Tipo del documento:
Article